The X Posts
An info-share progression from stocktwits to X to substack.
Organic growth: unicellular (day to day posts on stocktwits) to multicellular (more refined, structured posts on X but still random) to detailed articles on substack (purposeful, organized, productive). Here are the core posts on X, covering an array of topics in no particular order other than posting date. Many of these posts formed the basis for 2 - The Killer Nobody Names which calls out inflammation from its many hiding places.
1 Three of Five detailed
3in5saved@3in5saved
Worldwide, of the 60 million deaths reported each year, “3 of 5 people die due to chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes." ncbi.nlm.nih.gov/books/NBK49317…
According to the WHO, as of 6:15pm CET, 8
7:04 PM · Nov 9, 2023 · 6.17K Views
1 Repost · 5 Likes
2 How Gohibic works
3in5saved@3in5saved
How does Gohibic (vilobelimab) control inflammation? It binds to C5a preventing connection to a receptor known as C5aR, and in so doing, amongst other things, reduces the chemotactic effect of bringing too many activated neutrophils to the site of infection. Simple, right?
No,
2:33 PM · Nov 10, 2023 · 1.47K Views
2 Reposts · 4 Likes
3 Vilo not being used in US ICUs
3in5saved@3in5saved
Sepsis is an overwhelming immune response to an infection, which sends a chain reaction through the body that can result in tissue damage, multi-organ failure and death. sepsis.org/sepsis-basics/…
This overwhelming immune response begins with inflammation. One would think that
12:24 PM · Nov 11, 2023 · 524 Views
2 Replies · 2 Likes
4 NIH not supporting Vilo
3in5saved@3in5saved
#Gohibic #NIH Just two lives saved when Gohibic could have saved upwards of thousands more, from both death and further diminished quality of life due to organ damage.
A quote in regards to the National Institutes of Health (NIH):
One of the goals of the NIH is to expand the
12:52 PM · Nov 12, 2023 · 930 Views
2 Reposts · 6 Likes
5 Vilo in PG, effect on other organs
3in5saved@3in5saved
#Gohibic #InflaRx #HeartHealth “You cannot change your history of COVID-19 infections but if you’ve ignored other heart risks, like high [dietary] cholesterol or blood pressure, poorly controlled diabetes or smoking, now’s the time to change that.” milwaukeeindependent.com/newswire/profo…
It’s
O2 @O248528307
Pyoderma Gangrenosum (PG) an autoimmune condition with high unmet need. Orphan drug and fast track status granted. Awaiting feedback from FDA related to a P3 study. Imagine the pain day 1 and the improvement of life quality day 189. $IFRX
4:32 PM · Nov 14, 2023 · 641 Views
2 Reposts · 5 Likes
6 The value of this biotech
3in5saved@3in5saved
#Gohibic #investment $IFRX The C5a-C5aR signaling axis, adding more inflammation by way of C5a binding to its receptor, C5aR, initiating an inflammatory signaling process, like pressing 📞on your phone to invite more friends to a party, an analogy detailed in
3in5saved @3in5saved
How does Gohibic (vilobelimab) control inflammation? It binds to C5a preventing connection to a receptor known as C5aR, and in so doing, amongst other things, reduces the chemotactic effect of bringing too many activated neutrophils to the site of infection. Simple, right?
No,
12:32 PM · Nov 15, 2023 · 1.78K Views
2 Reposts · 3 Likes
7 Big green events
3in5saved@3in5saved
#Gohibic #Vilo #inflammation $IFRX
The stuff: Gohibic (vilobelimab, Vilo), a globally patented, highly selective and potent blocking monoclonal antibody that can control the primary inflammatory booster, C5a. Controlling Inflammation reduces organ damage, an effort – from micro
12:06 PM · Nov 16, 2023 · 484 Views
4 Reposts · 4 Likes
8 That much potential
3in5saved@3in5saved
#Gohibic #Vilo #CKD Recently, Dr. Taapken, the CFO for InflaRx, had this to say in regards to future company plans: “on the partnering side, we are now starting to discuss our programs with a variety of pharmaceutical companies because we feel in certain areas these drugs bear so
4:06 PM · Nov 18, 2023 · 2.89K Views
6 Reposts · 11 Likes
9 Fallacy post
3in5saved@3in5saved
#Gohibic controls #inflammation.
We see cause and effect arguments shared everyday on Xtwitter, many of which leading to misinformation if not disinformation. These types of fallacies can be harmful and very costly; it should be the responsibility of the millions of people who
3:53 PM · Nov 23, 2023 · 765 Views
2 Reposts · 4 Likes
10 NLR and disease severity
3in5saved@3in5saved
#Gohibic controls #inflammation.
With only, at most, 2 lives saved last quarter instead of upwards of 2000 lives saved, had Gohibic (Vilo) been better utilized in saving elderly Americans dying from an overwhelming inflammatory immune response to infection, we’ll leave it to the
4:49 PM · Nov 24, 2023 · 620 Views
1 Reply · 2 Likes
11 Living on Venus
3in5saved@3in5saved
#Gohibic controls #inflammation.
Too close to the Sun, too much heat: solarstory.net/img/articles/b…
Uncontrolled inflammation alongside controlled inflammation: news.uchicago.edu/story/was-venu…
A loved one trying to live on Venus: washingtonpost.com/health/elderly…
Vilo please.
1:37 PM · Nov 27, 2023 · 211 Views
3 Likes
12 CDC Nov 22 report
3in5saved@3in5saved
#Gohibic controls #inflammation. 12,045 lives lost last quarter, the CDC reporting 7,573 so far this quarter.
It’s not covid that kills; it’s the overwhelming inflammatory immune response to a covid infection, damaging lung tissue that can lead to long-term organ dysfunction if
4:29 PM · Nov 28, 2023 · 411 Views
1 Repost · 4 Likes
13 Executive summary, good/bad
3in5saved@3in5saved
Executive Summary 🧑🔬🧑⚕️🧑🦽
❌misinformation: BAD
✅facts: GOOD
❌uncontrolled #inflammation, viral sepsis, inflammatory comorbidities, death: BAD
✅#Gohibic: GOOD 🧠🫀🫁
3in5saved @3in5saved
#Gohibic controls #inflammation.
We see cause and effect arguments shared everyday on Xtwitter, many of which leading to misinformation if not disinformation. These types of fallacies can be harmful and very costly; it should be the responsibility of the millions of people who
12:15 PM · Nov 29, 2023 · 245 Views
1 Repost · 4 Likes
14 Executive summary, NFL
3in5saved@3in5saved
Executive Summary – #Gohibic enhances immune function.
🧑🔬Neutrophils (white blood cells) clear pathogens but can also damage organs.
📉Gohibic better enables immune homeostasis by lowering NLR (neutrophil to lymphocyte ratio).
✅Control neutrophil proliferation, save lives.
3in5saved @3in5saved
#Gohibic controls #inflammation.
With only, at most, 2 lives saved last quarter instead of upwards of 2000 lives saved, had Gohibic (Vilo) been better utilized in saving elderly Americans dying from an overwhelming inflammatory immune response to infection, we’ll leave it to the
2:01 PM · Nov 30, 2023 · 325 Views
1 Repost · 3 Likes
15 Repost of #2
3in5saved@3in5saved
#Gohibic (Vilo) controls #inflammation. Vilo (blue) binds to C5a (red), controlling inflammation, controlling organ damage, keeping the party to a low roar.
3in5saved @3in5saved
How does Gohibic (vilobelimab) control inflammation? It binds to C5a preventing connection to a receptor known as C5aR, and in so doing, amongst other things, reduces the chemotactic effect of bringing too many activated neutrophils to the site of infection. Simple, right?
No,
4:57 PM · Dec 2, 2023 · 307 Views
1 Repost · 3 Likes
16 Long-standing truth
3in5saved@3in5saved
It isn’t a virus that will send you to hospital; it’s your inflammatory immune response to the infection.
☠️Uncontrolled inflammation kills.
✅#Gohibic controls #inflammation
💡A long-standing truth that is seldom spoken: content.time.com/time/subscribe…
11:50 AM · Dec 4, 2023 · 237 Views
1 Like
17 Days and deaths
3in5saved@3in5saved
#Gohibic (Vilo) controls #inflammation
🕜Number of days since start of the pandemic:
1⃣3⃣9⃣4⃣ days
🆘Number of covid deaths reported to the CDC in 2023 (so far):
6⃣3⃣6⃣9⃣4⃣ deaths
When antiviral treatments fail…
✅Vilo please.
12:30 PM · Dec 6, 2023 · 512 Views
2 Likes
18 This much potential
3in5saved@3in5saved
C5a-C5aR signaling axis biotech: This Much Potential... #Gohibic #Vilo #InflaRx $IFRX
Common inflammatory comorbidities associated with severe covid, alongside CDC measures of the US population:
🔸Hypertension: 48% of adults
🔸Diabetes: 11.6% total (prediabetes in 48.8% 65
3in5saved @3in5saved
#Gohibic #Vilo #CKD Recently, Dr. Taapken, the CFO for InflaRx, had this to say in regards to future company plans: “on the partnering side, we are now starting to discuss our programs with a variety of pharmaceutical companies because we feel in certain areas these drugs bear so
12:16 PM · Dec 7, 2023 · 552 Views
1 Repost · 2 Likes
19 Dead lungs
3in5saved@3in5saved
#Gohibic (#Vilo) controls #inflammation.
It took 7000 articles relating to smoking and disease before the US Surgeon General publically acknowledged the danger back in 1964.
Currently there are over 5000 articles relating to the C5a-C5aR signaling axis and inflammatory disease.
2:45 PM · Dec 11, 2023 · 427 Views
2 Likes
20 Organ damage we see and don’t
3in5saved@3in5saved
Uncontrolled #inflammation causes organ damage.
Organ damage that we can see: Pyoderma Gangrenosum, Hidradenitis Suppurativa, Cutaneous Squamous Cell Carcinoma.
Then there’s what we can’t see, such as lung damage due to severe covid…
1:59 PM · Dec 12, 2023 · 327 Views
1 Reply · 4 Likes
21 Lack of inflammation policy
3in5saved@3in5saved
The greatest threat to life on #Earth – even more devastating than the dino extinction event from 66M years ago – is #addiction. Despite our common knowledge about tobacco and alcohol, the CDC still reports that “16 million Americans are living with a disease caused by smoking”
12:57 PM · Dec 13, 2023 · 143 Views
1 Like
22 Vehicle-alcohol analogy
3in5saved@3in5saved
#Gohibic #health #ArriveAlive The CDC indicates that “32 people in the US are killed every day in crashes involving an alcohol-impaired driver—this is one death every 45 minutes.” Removing the vehicle from the equation is the quickest, safest remedy; secondary is control of
3:03 PM · Dec 14, 2023 · 185 Views
2 Likes
23 Inflammation with ChatGPT
3in5saved@3in5saved
I used ChatGPT to learn about #inflammation and #Gohibic (Vilo). Before doing so…
I used Google to learn about ChatGPT chat.openai.com/auth/login:
- “training ChatGPT on a single GPU would take 355 years…[but] was trained across 25,000 GPUs and finished in a matter of days.”
-
11:28 AM · Dec 15, 2023 · 797 Views
1 Repost · 4 Likes
24 Ten days on from post 17
3in5saved@3in5saved
#Gohibic (Vilo) controls #inflammation
10 days on…
3,377 more covid deaths, the total now for 2023 at 67,071 deaths reported to the CDC.
✅Vilo please
3in5saved @3in5saved
#Gohibic (Vilo) controls #inflammation
🕜Number of days since start of the pandemic:
1⃣3⃣9⃣4⃣ days
🆘Number of covid deaths reported to the CDC in 2023 (so far):
6⃣3⃣6⃣9⃣4⃣ deaths
When antiviral treatments fail…
✅Vilo please.
7:15 PM · Dec 16, 2023 · 281 Views
1 Repost · 4 Likes
25 Live Web Event
3in5saved@3in5saved
What’s 100,000km long and lined by a single layer of cells that if spread out would cover several thousand square meters? The endothelium: the tissue of the human circulatory system which provides blood to all 79 organs by function of the heart at the rate of 4.9 liters per
O2 @O248528307
The Role of C5a Inhibition in COVID-19: Clinical Insights and Survival Benefits
Date & Time: December 19, 2023, at 11:00 AM (PST)
Description: This informative webinar, sponsored by Sepsis Alliance and supported by InflaRX, delves into the critical role of the Complement System
2:53 PM · Dec 18, 2023 · 505 Views
2 Likes
26 Don’t Flush DOWN
3in5saved@3in5saved
A sustainable solution: Controlling Inflammation for better #health
Alternatively we can always ignore the threat:
Don’t Flush DOWN
10:08 AM · Dec 19, 2023 · 187 Views
2 Likes
27 We are nature
3in5saved@3in5saved
Controlling Inflammation is the way of life, from micro to macro.
Watch “WE ARE NATURE” by @chadhodgsondop on #Vimeo vimeo.com/548356741?ref=…
6:11 AM · Dec 20, 2023 · 214 Views
3 Likes
28 6.8 million likes
3in5saved@3in5saved
At over 6.8 million likes, the most acknowledged tweet of all time was about Chadwick Boseman who sadly lost his life to colon cancer. For this deserved recognition of a great actor and person, perhaps the greater tragedy is the lack of recognition for our most significant cause
1:26 AM · Dec 1, 2023 · 216 Views
1 Like
29 Predictable and Preventable
3in5saved@3in5saved
Predictable and Preventable were the millions of global deaths due to this pandemic, which is still taking over 1000 lives every week in the US. Thankfully we now have #Gohibic (Vilo) gohibic.com for care of the most vulnerable within the ICU, controlling the cause
10:15 AM · Dec 27, 2023 · 256 Views
1 Like
30 Sepsis to amputation
3in5saved@3in5saved
Controlling Inflammation is the only sustainable solution. #Gohibic controls #inflammation. #Sepsis can lead to the need for amputation. Why? Dysregulated inflammation that leads to organ damage. Dysregulated inflammation in all forms: severe covid, heart disease, and
6:01 PM · Jan 2, 2024 · 232 Views
1 Reply · 2 Likes
31 C5a as center of inflammation
3in5saved@3in5saved
C5a is the center of #inflammation. #Gohibic (Vilo) binds to C5a, thereby Controlling Inflammation.
Neutrophils are key to cellular damage as a result of inflammatory disease. “C5a is a key chemo-attractant and a strong activator of neutrophils and Neutrophil Extracellular
8:03 PM · Jan 9, 2024 · 190 Views
1 Like
32 Vilo sales potential
3in5saved@3in5saved
At just 5% market saturation in the first year of #Gohibic (Vilo) treatment in care of moderate to severe HS patients in the US, this would equate to $3.2B in sales equalling a 10x increase in price target over the current $21 target which is based on an estimated $320M in Vilo
O2 @O248528307
@Quick2smile @3in5saved It’s obvious that this space will become some kind of standard of care everything inflammation in the near future. What kind of sales numbers should we expect? 👆
10:51 AM · Jan 10, 2024 · 767 Views
1 Reply · 1 Repost · 2 Likes
33 Instinctive humans
3in5saved@3in5saved
We humans are instinctively born knowing what to do. It is only through learned behavior of normalized abuse to body and surroundings that we find disharmony.
The disharmony of uncontrolled #inflammation, of that which impacts healthy immune function, to that which impacts
Buitengebieden @buitengebieden
Kindness matters.. 😊
5:53 PM · Jan 18, 2024 · 151 Views
1 Like
34 Heart disease
3in5saved@3in5saved
#Gohibic controls #inflammation. A significant inflammatory challenge such as covid can impact the normal function of multiple organs, particularly the lungs and the heart. With the top global killer being heart disease, often a silent killer, already a compromised organ in a
2:39 PM · Jan 23, 2024 · 219 Views
1 Like
35 Wainwright’s calculator
3in5saved@3in5saved
#Gohibic (Vilo) #InflaRx web.archive.org/web/2020102408…
ChemoCentryx (CCXI), before Amgen bought them out for $3.7B for access to an oral C5aR inhibitor, avacopan, showed Wainwright from back in May 2020 giving a pt of $69 (mcap of $4.75B), just on p3 data of one study (AAV), long
stock setter @MarcJacksonLA
$IFRX
HC Wainwright lowers InflaRx price target to $8 from $9, Buy rating.
10:12 PM · Jan 25, 2024 · 250 Views
2 Likes
36 C5a-C5aR axis of value
3in5saved@3in5saved
The C5a-C5aR signaling axis itself is what is of value: inhibit the receptor (904) or block C5a, the protein that is the primary driver of inflammation (#Gohibic, Vilo); signaling (chemotaxis) is then significantly reduced, decreasing for example the cellular damaging effects of
Dogtor🎰📈 @Dogtor01416800
@Biotech_Beast Correct, from my understanding, 904 is more valuable asset, rather than Vilobelimab, however the nearest catalyst for $IFRX is the IFX-1 Ph.2 combination arm data, which is due in 1H 24
3:26 PM · Feb 1, 2024 · 321 Views
1 Repost · 3 Likes
37 IFN production
3in5saved@3in5saved
#Gohibic gohibic.com Controlling Inflammation for the win. #plantbased or #keto? With 10s of trillions of cells in the human body, the protective job of our immune systems is substantial. Besides the primary importance of the inflammatory response, another key
4:27 PM · Feb 12, 2024 · 259 Views
1 Reply · 1 Like
38 Inflammation episode 1
3in5saved@3in5saved
Controlling Inflammation is the only sustainable solution. Thankfully we have #Gohibic gohibic.com for the lifesaving care of IMV/ECMO viral #sepsis patients.
There are other means by which to control one’s level of #inflammation. Learn about it tonight at 8pm
8:18 PM · Feb 19, 2024 · 470 Views
1 Reply · 1 Repost · 3 Likes
39 Inflammation episode 2
3in5saved@3in5saved
Continuing tonight at 8pm Eastern, Episode 2 Microbiome Solutions: Prebiotics & Probiotics for Beating Inflammation. inflammationseries.com/?sl=viral
As identified in episode 1, dysregulated inflammation plays havoc on our organs – skin, heart, kidneys, liver, pancreas, lungs, brain –
3in5saved @3in5saved
Controlling Inflammation is the only sustainable solution. Thankfully we have #Gohibic https://t.co/Z21kv3vL88 for the lifesaving care of IMV/ECMO viral #sepsis patients.
There are other means by which to control one’s level of #inflammation. Learn about it tonight at 8pm
10:30 AM · Feb 20, 2024 · 197 Views
1 Reply
40 Happy World Encephalitis Day
3in5saved@3in5saved
Happy World Encephalitis Day. Encephalitis is inflammation of the brain, which can occur during a viral infection, adding risk to an existing state of chronic inflammation, leading to a dysregulated inflammatory response which in turn can lead to organ damage, of the lungs,
5:14 PM · Feb 22, 2024 · 160 Views
41 Vilo is very important
3in5saved@3in5saved
$IFRX The global #sepsis market alone warrants appreciation for #Gohibic (Vilo). Slow-acting, metabolism-dependent C5aR oral inhibitors aren’t going to save Grandma dying from viral sepsis.
The C5a-C5aR signaling axis is the focus. Controlling this signaling is the biotech.
LawDawg050 @LawDawg050
$IFRX is INF904 a sleeping giant? Lack of near term catalyst a concern and vilobelimab a distraction IMO.
5:25 PM · Feb 23, 2024 · 1.09K Views
4 Reposts · 7 Likes
42 Retail, buy in confidence
3in5saved@3in5saved
I'm always happy to share what I know about lifesaving #Gohibic (Vilo), best in class in Controlling Inflammation. C5a-C5aR signaling biotech has been proven several times now to be effective in treating organ damage, long before it was done correctly with Vilo, back when the
Gentleman @LHZ656
@3in5saved Thank you for your recommendation. I have read the discussions over the past year and I think everyone is pessimistic about the current commercialization of the company's GOHIBIC https://t.co/0a09S0hT1u too
4:41 PM · Feb 24, 2024 · 356 Views
1 Repost · 2 Likes
43 IFRX absurdly priced
3in5saved@3in5saved
$IFRX (#InflaRx), Controlling Inflammation, represents one of the greatest investment opportunities of all time, especially for that of the patient, knowledgeable retail investor, willing to wait it out on an extremely low risk, high reward opportunity. Dysregulated inflammation
5:16 PM · Feb 26, 2024 · 1.11K Views
1 Reply · 1 Repost · 8 Likes
44 IFRX for the win
3in5saved@3in5saved
We have an anti-obesity drug hitting a valuation of over $7B this morning, not even in a p3 yet, ironic too considering obesity is a major source of chronic #inflammation, a pillar of that which leads to #sepsis, the land of #Gohibic treatment. Therefore best to remember that we
Dogtor🎰📈 @Dogtor01416800
@3in5saved (2) is so much overlooked by bio-funds?
2) how do you assess $IFRX management’s credibility?
3) pretty sure, you listened to all their calls - do they put emphasis on partnering with a more experienced companies?
4) what is you realistic PT and how you estimate it?
THANKS!
4:24 PM · Feb 27, 2024 · 2.31K Views
1 Reply · 3 Reposts · 4 Likes
45 Vitamin D and covid
3in5saved@3in5saved
Controlling #Inflammation is the only sustainable solution; whatever we can do in that regard to avoid dying from viral #sepsis, the cause of the twenty thousand covid deaths reported to the CDC in the last three months of 2023. I was just going to post that great Ninja Nerd
Brian Remy @briancremy
@JanJekielek Thanks for posting Jan, excellent confirmation of what @NinjanerdSci had presented back in 2021 (along with @doctorcole):
5:18 PM · Mar 2, 2024 · 341 Views
1 Like
46 Odds of dying
3in5saved@3in5saved
#Gohibic (Vilo) gohibic.com A worsening covid infection – the fear of death – leads to hospital admission. And for good reason: in regards to covid, as reported to the CDC in the past 34 weeks, there have been 647,648 new hospitalizations and 45,951 deaths.
That’s
9:28 PM · Mar 4, 2024 · 229 Views
1 Like
47 ICU through sodium
3in5saved@3in5saved
Before ending up in an ICU, dying from viral #sepsis as a result of uncontrolled #inflammation leading to multi-organ failure, focus on prevention, a primary action being to reduce sodium intake. Sure, tell us something we don’t know. But did you know this…
A Lancet paper,
2:37 PM · Mar 7, 2024 · 428 Views
2 Likes
48 Nephrons and inflammation
3in5saved@3in5saved
#InflaRx controls #inflammation, treats viral #sepsis, keeps Grandma smiling. gohibic.com
Allow me to introduce you to a family member, Nephron; a cute little guy isn’t he. We have about a million of them in each kidney, tiny filters, keeping the good stuff in and
3:17 PM · Mar 11, 2024 · 469 Views
2 Reposts · 3 Likes
49 What are you waiting for
3in5saved@3in5saved
#InflaRx $IFRX biotech controls inflammation. You might be wondering, of this biotech, what of scientific foundation, signaling control, and proven market?
C5a-C5aR signaling: control the binding of C5a to its receptor C5aR, control inflammation.
Impact on heart muscle cell
3:55 PM · Mar 12, 2024 · 764 Views
1 Reply · 3 Reposts · 5 Likes
50 Neurological disorders
3in5saved@3in5saved
Controlling #Inflammation for the win.
“The number of people living with or dying from disorders of the nervous system has risen dramatically over the past three decades, with 43% of the world’s population – 3.4 billion people – affected in 2021, according to
5:22 PM · Mar 15, 2024 · 173 Views
51 Seventh annual sepsis alliance
3in5saved@3in5saved
Currently underway is the livestream of the 7th Annual Meeting of
the European #Sepsis Alliance. #inflammation #Gohibic (Vilo)
youtube.com/watch?v=ERw5O1…
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, affecting 10 of millions of
3:09 PM · Mar 18, 2024 · 205 Views
1 Reply · 3 Likes
52 Q4 2023, how many saved
3in5saved@3in5saved
$IFRX C5a-C5aR signaling: control the binding of C5a to its receptor C5aR, control #inflammation, treat viral #sepsis.
#InflaRx announced commercial launch of #Gohibic (Vilo) on June 21, 2023.
According to weekly reporting into the CDC covid.cdc.gov/covid-data-tra…, from July 1, 2023
2:57 PM · Mar 19, 2024 · 543 Views
2 Replies · 5 Likes
53 Grandma needlessly died
3in5saved@3in5saved
#Gohibic (Vilo) During the last 3 months of 2023, twenty thousand Americans died from a covid infection, mostly of the elderly, someone’s Grandma that died, in an ICU, dying from a dysregulated immune response to infection.
Dying from viral #sepsis, from organ failure.
Dying
7:43 AM · Mar 22, 2024 · 4.7K Views
2 Replies · 2 Reposts · 4 Likes
54 Death by viral sepsis
3in5saved@3in5saved
Death by viral #sepsis is an awful way to go, dying from dysregulated immune function as a result of uncontrolled #inflammation. #Gohibic (Vilo) please.
The most deadly inverse relationship: decreased immune function leading to increased viral mutation.
1.5 billion cows. 25
4:08 PM · Apr 4, 2024 · 273 Views
1 Repost · 3 Likes
55 Vilo treating influenza
3in5saved@3in5saved
Here’s a paper from 2016 discussing aspects of the dysregulated immune response to influenza A viral (IAV) infection. There’s mention of C5a, a protein of the immune system regarded as the primary driver of inflammation, that which #Gohibic (Vilo) targets in order to treat viral
5:57 AM · Apr 8, 2024 · 694 Views
1 Repost · 4 Likes
56 Predicting pandemics
3in5saved@3in5saved
#Gohibic #sepsis #inflammation: Dysregulated immune function as a result of chronic inflammation combined with an infectious disease and ease of travel, the recipe for pandemic certainty. In birds and mammals of all varieties, Controlling Inflammation is the only sustainable
John Cullen 🐓 @I_Am_JohnCullen
You know what's weird?
January, 2017
Dr Fauci predicted a "Surprise Outbreak for the next administration."
September, 2017:
H7N9 went highly pathogenic in China.
That's a strange coincidence..
Almost like Dr Fauci knew it would happen..?
(Good thing he funded Kawaoka > GoF)
6:52 PM · Apr 16, 2024 · 223 Views
1 Repost · 1 Like
57 HS, INF904, and m-HiSCR
3in5saved@3in5saved
There are over 6000 publications dating back to the 70s that detail the role of C5a/R signaling – the primary driver of inflammation – in numerous inflammatory diseases. In addition, #Gohibic (Vilo) has consistently been shown to effectively and safely return C5a to normal
O2 @O248528307
📉 Years ago, $IFRX shares plummeted from $52 to $1.45 after a study on hidradenitis suppurativa—a chronic and painful skin condition. As a shareholder, I see the need to clarify what really happened. #HidradenitisSuppurativa
🔬 Niels detailed in the last CC that the trial's
10:40 PM · Apr 20, 2024 · 291 Views
1 Repost · 3 Likes
58 Dr. Zychlinsky’s NETs
3in5saved@3in5saved
At current price, it’s about as certain as it gets that one can make 50x to 100x on their money, invested in $IFRX. As such, you can afford to buy this guy a beer, while discussing your favorite topic: the role of neutrophils in immune function. Here is Dr. Arturo Zychlinsky
1:27 PM · Apr 22, 2024 · 948 Views
4 Reposts · 7 Likes
59 Practical and essential defense
3in5saved@3in5saved
Practical and essential defense against many threats from many shores: H5N1, H7N9, H1N1, H3N2, and evolving coronaviruses SARS-CoV-2, SARS-CoV-1, and MERS-CoV-1. #Gohibic (Vilo) please.
https://t.co/hXsPIuxy35
@StreetCred2018 @StreetCred2017
@CDCDirector @US_FDA @CDCgov Grok: Based on public studies and EMA, should InflaRx $IFRX #Gohibic be stocked by @US_FDA for treatment of new avian flu variants?
@3in5saved @O248528307 @Quick2smile
Based on the information provided, it appears that stockpiling Gohibic (vilobelimab) for potential new avian
11:41 AM · Apr 24, 2024 · 413 Views
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60 Vilo, before it’s too late
3in5saved@3in5saved
#InflaRx @US_FDA @EMA_News “The threat of a pandemic remains high, and we urge international leaders to reach an agreement on a pandemic accord before it is too late.”
It was too late decades ago, with plenty of warnings along the way such as from WHO, 2007: “The biggest fear is
2:57 PM · Apr 26, 2024 · 229 Views
1 Like
61 Viral vascular injury
3in5saved@3in5saved
Side roads or the vascular highway, how would you want to efficiently travel? Where there is pathogenic threat, there is inflammation and the tissue damage that it can cause when uncontrolled.
Some quotes from a 2006 paper on H5N1 study in cats:
“demonstrates that H5N1 virus
Danielle Beckman @DaniBeckman
I have been seeing the same. #COVID19 is a serious vascular disease. https://t.co/QQ6UexIFv2
2:23 AM · Apr 27, 2024 · 493 Views
1 Reply · 1 Repost · 3 Likes
62 Not so smart Vilo mcap
3in5saved@3in5saved
Vilo please.
3in5saved @3in5saved
@StreetCred2017 @Dogtor01416800 @VLESHCHOU The remarkable thing about $IFRX is that the 90% price drop back in June 2019 wasn’t because #InflaRx anti-C5a #Gohibic (Vilo) didn’t work in the H2 p2 trial – 63% reduction in draining tunnels vs 18% placebo, at least 50% HiSCR at 1200 Q2W dosing, which was in line with Humira’s
3:37 PM · Apr 29, 2024 · 177 Views
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63 Not so beautiful fractals
3in5saved@3in5saved
Before the need for reactionary control, the consequence of replication, best to focus on addressing root cause. Control Inflammation within host to prevent exponential inflammatory growth across hosts, across countries, across continents. #Gohibic (Vilo) please, at market,
3:53 PM · Apr 30, 2024 · 127 Views
1 Like
64 Animal cruelty, human catastrophe
3in5saved@3in5saved
Thankfully we now have #Gohibic (Vilo) to control the primary driver of #inflammation, C5a-C5aR signaling, able to therefore treat dysregulated immune function that can otherwise lead to viral #sepsis in the case of SARS-CoV-2 infection, noting other pathogens of similar
3:58 PM · May 1, 2024 · 361 Views
2 Replies · 4 Reposts · 5 Likes
65 PG sales first year
3in5saved@3in5saved
#Gohibic (Vilo) under EUA to treat viral #sepsis as caused by a dysregulated immune response to a SARS-CoV-2 viral infection – controlling #inflammation by controlling C5a-C5aR signaling – this pipeline-in-a-product is now under clinical study to treat pyoderma gangrenosum (PG),
O2 @O248528307
Amgen's TAVNEOS raked in $51M this quarter! What if InflaRx's Vilobelimab gets approved for pyoderma gangrenosum? Projecting sales: $100M in 2025, $200M in 2026, $300M in 2027, $400M in 2028, and $500M in 2029. With a 30% discount rate & 60M shares outstanding, the net present
3:12 PM · May 3, 2024 · 498 Views
2 Reposts · 3 Likes
66 An immunocentric, global problem
3in5saved@3in5saved
“Ecology of avian influenza viruses in a changing world,” the title of a 2010 paper which I read in August of 2021, about year into the #InflaRx 46 hospital, 9 country, international study of #Gohibic (Vilo) in care of viral #sepsis patients as a result of SARS-CoV-2 infection
4:27 PM · May 4, 2024 · 245 Views
1 Reply · 1 Repost · 2 Likes
67 INF904 for CoV CKD patients
3in5saved@3in5saved
Yet another potential application for #InflaRx pipeline-in-a-product #INF904: “mucosal immune responses to SARS-CoV-2 infection may result in the overactivation of systemic and renal local complement system as one hit, increased glomerular deposition of Gd-IgA1 as the other hit.
@StreetCred2018 @StreetCred2017
@3in5saved New study showing that post COVID, #IgaNephropathy can flare via C5 of complement system overreaching. $IFRX #gohiboc may help. Many new #IGA treatments compared to years back.
https://t.co/eQFxXrisGn
@IGANFoundation @ASNKidney @Kidney_Research
4:06 PM · May 6, 2024 · 277 Views
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68 Don’t stress over inflammation
3in5saved@3in5saved
Pro-inflammatory cytokines are signaling molecules that play a crucial role in promoting inflammation. C5a-C5aR signaling is upstream of the cytokine network. Therefore control this signaling on the C5a side of the axis with #Gohibic (Vilo) or with #INF904 on the C5aR side,
Bee Happy. Bee Well In You 🐝🍯 @beewellinyou
#MentalHealthAwarenessMonth Have a #stress free week to ensure that your wellbeing helps you keep a healthy routine and healthy habits during your week so your #emotional wellbeing stays in good shape too. It's always good to fill up your own cup. Taking care of you.
1:57 PM · May 7, 2024 · 246 Views
2 Replies · 1 Like
69 No Vilo: ignorance or negligence
3in5saved@3in5saved
#sepsis #inflammation #Gohibic #InflaRx $IFRX
In the last 6 months ending March 2024, 40,657 covid deaths were reported to the CDC, of which upwards of 27,132 lives could have been saved had Gohibic (Vilo) been used in treatment of next-to-death covid patients.
27,132 lives,
2:58 PM · May 14, 2024 · 363 Views
1 Reply · 2 Reposts · 4 Likes
70 Methods of controlling inflammation
3in5saved@3in5saved
Controlling Inflammation for the win. Ideally through external control methods as outlined in the repost. Otherwise through internal means with use of #Gohibic and #INF904, the game changing products of #InflaRx, from treating viral #sepsis to treating serious skin diseases
Dr. BP | Metabolism 2.0 @DrBPHealth
We cannot escape aging.
However, inflammation is a major accelerator of aging.
Lower your inflammation = slow down your aging
I will cover the tests that measure your inflammation levels to see where you stand.
THREAD
5:17 PM · May 14, 2024 · 229 Views
1 Reply · 2 Likes
71 Plant-based milk for the win
72 GPT-4 C5a-C5aR biotech valuation
3in5saved@3in5saved
$IFRX #InflaRx
💰In 1-2 years, $1-2B; in 2-5 years, $10-15B; in 5+ years, over $20B.
That’s the value OpenAI's GPT-4 architecture, chatgpt.com, puts on C5a-C5aR signaling control biotech, noting that #Gohibic (Vilo) is the only anti-C5a biotech on the market, and
@StreetCred2018 @StreetCred2017
@Dogtor01416800 Next up: In just 3 weeks, Key Option Leaders (KOL) share thoughts on #INF904 in a 2 hour live webinar on #PG #CSU #HS
With equity down from 97% from $50 to $1.5 (<cash value), expect action as #KOLsHaveFriends within
$XBI world.
Must register to listen and learn latest on
3:50 PM · May 18, 2024 · 542 Views
2 Replies · 1 Repost · 6 Likes
73 Vilo need in the US and EU
3in5saved@3in5saved
The recent #InflaRx press release, showing that #Gohibic (Vilo) provides a relative reduction in covid mortality upwards of 84.6% over standard of care, should be cause for concern: in the last year, why have tens of thousands of Americans tragically lost their lives due to
12:42 PM · May 22, 2024 · 298 Views
2 Replies · 2 Reposts · 3 Likes
74 The C5a/R global market is BIG!
3in5saved@3in5saved
$IFRX The global market for C5a-C5aR signaling control biotech, Controlling Inflammation, is BIG!
Really big. 10s to 100s of $ billions big. #InflaRx has the only anti-C5a product, #Gohibic (Vilo), at market, with their C5aR inhibitor, #INF904, showing best in class potential
1:44 PM · May 23, 2024 · 661 Views
1 Reply · 1 Repost · 4 Likes
75 Canada and the good fight
3in5saved@3in5saved
No one can fault the want to survive, to protect one’s interests and that of their immediate family. Leaders however should ideally maintain a wider focus and therefore should make decisions that optimize the survival of all families, the concept behind #OneHealth. To that, we
4:05 PM · May 28, 2024 · 288 Views
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76 Top 10 HxNx pandemic threats
3in5saved@3in5saved
In concern of pandemic threats, besides test, contain, and vaccinate programs, priority should also be placed on preparation for treatment of viral #sepsis, the dysregulated immune response to viral infection leading to organ failure, the ultimate cause of death from such
4:46 PM · Jun 3, 2024 · 178 Views
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77 INF904 R&D event summary
3in5saved@3in5saved
Thank you #InflaRx $IFRX for organizing the recent R&D Event which detailed the exciting promise of oral C5aR inhibitor, #INF904. Both the presentation and a recording of the webcast are now available at inflarx.de/Home/Investors….
Some Highlights
▶️page 16: the C5a-C5aR
1:30 PM · Jun 7, 2024 · 1.5K Views
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78 What motivates InflaRx biotech
3in5saved@3in5saved
That which motivates the need for Controlling Inflammation; that which motivates the need for #InflaRx biotech, for #Gohibic and #INF904…
“Spillover of zoonoses into human populations stems ultimately from our ways of life and how they shape the human–animal interface. Our
4:53 PM · Jun 8, 2024 · 383 Views
1 Reply · 3 Reposts · 5 Likes
79 Jokes about C5a-C5aR signaling
3in5saved@3in5saved
GPT-4o (chatgpt.com), assume you are Arnold Schwarzenegger and provide dialogue acting as a stand-up comedian with focus on jokes regarding C5a-C5aR signaling biotech as it relates to treatment of inflammatory diseases. #InflaRx #Gohibic #INF904
Arnold walks on
1:50 PM · Jun 12, 2024 · 212 Views
2 Likes
80 H5N1 contaminated product risk
3in5saved@3in5saved
#Gohibic (Vilo) treats viral #sepsis, the dysregulated immune response to viral infection leading to inflammatory organ damage resulting in significant negative impact on quality of life if not death.
Some stats
31: number of legal raw milk states
11: number of illegal raw milk
3:33 PM · Jun 13, 2024 · 709 Views
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81 Viral sepsis from many sources
3in5saved@3in5saved
#Gohibic controls #inflammation by controlling C5a levels. The C5a-C5aR signaling axis, part of one’s immune system, as noted in over 6000 research publications, is the primary driver of inflammation. This inflammatory signaling, when dysregulated, leads to tissue damage of
Dame Sa 🐝 3.5% @LongCovidHell
@TheWeek Covid and inflammation:
“HIV patients don’t die from the virus itself. They die from immune activation - high levels of inflammation that causes cancer, heart disease & liver disease. I’ve studied HIV for 20 years and found COVID very similar to HIV.”
https://t.co/yZhXF87BWL
3:24 PM · Jun 21, 2024 · 308 Views
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82 BARDA ARDS study with Vilo
3in5saved@3in5saved
“#ARDS affects more than 190,000 people in the United States each year and results in an estimated 74,500 deaths and 3.6 million hospital days.” ncbi.nlm.nih.gov/pmc/articles/P…
In the struggle to just breathe, suffering from severe ARDS, “individuals may feel as if they are drowning or
BARDA @BARDA
We’ve selected host-directed therapeutics from @EdesaBiotech and InflaRx for inclusion in a phase 2 platform clinical trial to address acute respiratory distress syndrome (#ARDS). Learn more: https://t.co/eNiIDaej9o
11:32 AM · Jun 26, 2024 · 328 Views
1 Reply · 1 Repost · 3 Likes
83 Sepsis and ARDS
3in5saved@3in5saved
It’s all about levels of uncontrolled #inflammation. “#Sepsis is the body's extreme response to an infection.” #Gohibic (Vilo) is currently under emergency use authorization to treat an extreme response to a SARS-CoV-2 infection leading to the need for mechanical ventilation;
CDC @CDCgov
Anyone can get an infection, and almost any infection can lead to sepsis. One in three people who dies in a hospital had #sepsis during that hospitalization.
Understand more about this life-threatening medical emergency: https://t.co/W7DF9iLBxR
3:03 PM · Jul 1, 2024 · 233 Views
84 No more mopping up floors
3in5saved@3in5saved
#Gohibic/#INF904: C5a-C5aR signaling control please. Enough with incessantly mopping up floors.
Controlling Inflammation for the win.
3in5saved @3in5saved
@StreetCred2017 @vipintukur "C5a-C5aR signaling functions upstream of PI3K gamma signaling in the inflammatory process. C5a acts as a potent initiator of inflammation by binding to its receptor, which then activates PI3K gamma among other downstream signaling pathways. This hierarchical relationship allows
5:22 PM · Jul 5, 2024 · 255 Views
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85 Controlling the neutrophil tap
3in5saved@3in5saved
Morphic, going for $3.2B with a pipeline consisting of 4 drugs in pre-clinical study and one drug in p2b study of the very busy IBD space? Reminds me of when Pfizer paid $6.7B back in 2022 for Arena Pharmaceuticals, primarily to own etrasimod for IBD treatment.
“Pre-clinical
@StreetCred2018 @StreetCred2017
@COVID19_disease Congrats $MORF
Very nice to see.
1:46 PM · Jul 9, 2024 · 537 Views
1 Reply · 2 Reposts · 2 Likes
86 Feed and trust your gut
3in5saved@3in5saved
We’re not just feeding the pleasure center of the brain. Seems there’s more to the expression “trust your gut” than we realize, in recognizing the importance of feeding the gut, the second brain, vital to longevity and good health. The gut, made up of trillions of bacteria,
3:15 PM · Jul 15, 2024 · 140 Views
2 Likes
87 The fountain of demise
3in5saved@3in5saved
#InflaRx $IFRX biotech controls C5a-C5aR signaling: #Gohibic (Vilo) targets C5a; #INF904 targets C5aR.
Blocking IL-11 in the news as a potential path towards the fountain of youth. nature.com/articles/d4158…
Let’s generalize: taking personal ownership of one’s inflammatory
6:35 PM · Jul 18, 2024 · 436 Views
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88 The immune system as a work of art
3in5saved@3in5saved
Thank you sir for your contributions towards the pursuit of honesty and truth.
We should marvel at the complexity, beneficial redundancy, adaptability, resilience, power – the sheer beauty! – of the human immune system, 100s of millions of years in the making.
What could be a
Emmanuel @ejustin46
WHAT a STRANGE IDEA to think that immunity against SARS-CoV-2, would solely rely on a single protein, known as the Spike, and only be dependent on the functionality of neutralizing antibodies ! 🤔
Throughout the course of the pandemic, the Spike protein has dominated ...
2:48 PM · Jul 20, 2024 · 227 Views
2 Likes
89 Sepsis and Inflammation orgs unite
3in5saved@3in5saved
#InflaRx (inflarx.de) presented at the recent 16th World Congress on Inflammation (wci2024.org/en) regarding C5a inhibitor #Gohibic in controlling inflammation. linkedin.com/posts/inflarx_…
Been reading about inflammation related stuff for over 5 years now, a
6:06 PM · Jul 26, 2024 · 169 Views
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90 Know the cause of death
3in5saved@3in5saved
At least know the cause of death. It’s all around us, closing in, predictable and preventable.
Controlling Inflammation is the only sustainable solution.
3in5saved @3in5saved
@CDCgov Thank you for raising awareness about #sepsis, the dysregulated immune response to infection leading to multi-organ failure. WHO notes that “from data published in 2020, there were 48.9 million cases and 11 million sepsis-related deaths worldwide, representing 20% of all global
3:25 PM · Jul 29, 2024 · 163 Views
1 Like
91 Behave, Klebsiella pneumoniae
3in5saved@3in5saved
#Gohibic (Vilo) treats a dysregulated immune response to infection that can otherwise lead to death. Thank you, #InflaRx, as this biotech is of vital importance in an ICU setting where infection can be triggered by many kinds of pathogens, such as SARS-CoV-2 and others…
5:51 PM · Aug 3, 2024 · 272 Views
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92 Death by ignorance
3in5saved@3in5saved
In regards to #sepsis, a dysregulated immune response to infection leading to multi-organ failure – death by uncontrolled inflammation – the CDC reports that in the US per year
🚩33% of hospital deaths are attributed to sepsis
🚩1.7 million adults in America develop sepsis
3:06 PM · Aug 12, 2024 · 333 Views
1 Like
93 Better health through better leadership
3in5saved@3in5saved
Better health through better leadership. #Gohibic
3in5saved @3in5saved
@BNOFeed As reported to the @CDCgov https://t.co/2ggWFZu7qd, in 2023 there were a total of 75,563 deaths attributed to covid.
As of the latest reporting cycle, Oct 3, noting a reporting lag of about a month, in 2024 so far there are a total of 37,364 covid deaths.
13 weeks to go in
2:58 PM · Oct 7, 2024 · 359 Views
1 Reply · 3 Reposts · 3 Likes
94 ST discussions, a point in time
3in5saved@3in5saved
#InflaRx #Gohibic $IFRX
Here’s a summary of some recent discussions amongst well informed biotech investors in the complement research space. All about Controlling Inflammation. Join the party.
Pyoderma Gangrenosum (PG)
A horrible inflammatory disease with currently very
11:59 AM · Oct 22, 2024 · 792 Views
1 Reply · 3 Reposts · 7 Likes
95 Better health through better leadership #2
3in5saved@3in5saved
Better health through better leadership. #Gohibic
Billy Hanlon @bhanlon15
The Hill: 'We may think we’re done with COVID-19, but COVID-19 is not done with us'
"...long COVID, which is estimated to affect 5.3% of US adults in the U.S. (13.5M people), poses potentially serious and debilitating long-term health issues..."
https://t.co/jhF2aVDkgY
12:13 PM · Oct 31, 2024 · 131 Views
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96 Gohibic is cost effective
3in5saved@3in5saved
#Gohibic is cost effective. Let’s start using it. Save lives. Improve quality of life. Do better.
Roger Seheult, MD @RogerSeheult
We just got published!
Here's a antibody (vilobelimab) that binds a portion of the complement cascade to reduce inflammation and reduce deaths in severe C-19 patients (on the ventilator). Study showed that it was cost effective. Imagine adding sunlight!
https://t.co/k6qY0Ip6j1
12:18 PM · Oct 31, 2024 · 331 Views
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97 Covid deaths, a point in time
3in5saved@3in5saved
As appropriately and responsibly said, “COVID-19 is not done with us.” ca.news.yahoo.com/opinion-may-th…
#Gohibic #inflammation #sepsis #ARDS
Here are the latest counts as provided by the CDC (noting about a month in reporting lag). Compared to last year, this summer wave was more
8:20 PM · Nov 22, 2024 · 228 Views
1 Reply · 2 Reposts · 3 Likes
98 Me and my 50 healthcare friends
3in5saved@3in5saved
#InflaRx #Gohibic #sepsis #ARDS
Hi, it’s me and my 50 healthcare friends. I write as one here but remain hopeful for all, hence the use of we.
We wanted to let you know, citizens of this pathogen paradise, that we understand the two-step process: Prevention & Restoration.
12:06 PM · Nov 25, 2024 · 386 Views
1 Reply · 2 Reposts · 3 Likes
99 A vital 2-step process
3in5saved@3in5saved
At last update, the “JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab” study is expected to start on December 27. #Gohibic #InflaRx #ARDS
Comforting to know that ~60 sites in the US will be involved in this study, 60 hospitals that will
6:02 PM · Dec 6, 2024 · 6 Views
100 A refined 2-step process
3in5saved@3in5saved
Just read this post, prompting me to alter my understanding of the noted 2-step process. https://t.co/A2PLYOZR9a
Prof. Doherty won the Nobel Prize in Physiology or Medicine in 1996, alongside Prof. Zinkernagel, “for the discovery of how the immune system recognizes
3in5saved @3in5saved
At last update, the “JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab” study is expected to start on December 27. #Gohibic #InflaRx #ARDS
Comforting to know that ~60 sites in the US will be involved in this study, 60 hospitals that will
5:41 PM · Dec 7, 2024 · 262 Views
1 Reply · 1 Repost · 3 Likes
101 Summer of ’25…or 26
3in5saved@3in5saved
$IFRX #InflaRx
The promising best-in-class, pipeline-in-a-drug, #INF904 – destined to positively impact the health of millions of people – is now set on that inevitable path with first application in the study of chronic spontaneous urticaria (CSU) and hidradenitis suppurativa
7:35 PM · Dec 20, 2024 · 797 Views
1 Reply · 1 Repost · 5 Likes
102 Options for step 2 are very much lacking
3in5saved@3in5saved
The 2-step process:
1) manage immune inaction
2) manage immune overreaction (with #Gohibic)
We’re pretty good at step 1, as to options if not utilization. Timing and treatment options for step 2 are very much lacking, especially in this pathogen paradise powered by the global
6:59 PM · Jan 1, 2025 · 154 Views
1 Reply
103 Death by ARDS
3in5saved@3in5saved
As this Lancet paper points out, of the millions of lives lost to a SARS-CoV-2 infection, “the majority [are] via ARDS.” thelancet.com/article/S0140-…
Death by way of a dysregulated immune response to infection: death by way of uncontrolled inflammation.
As in the analogy of the risk
O2 @O248528307
1. Vilobelimab + Tocilizumab: A Powerful Combination in Inflammation Therapy
InflaRx's Vilobelimab and Roche's Tocilizumab could be the ideal duo to tackle severe inflammation in ARDS, pneumonia, and other immune-related conditions. Here’s why this is exciting:
6:29 PM · Jan 5, 2025 · 568 Views
2 Replies · 3 Reposts · 3 Likes
104 The enemy: H1N1
3in5saved@3in5saved
The Pan American Health Organization (PAHO), in existence since 1902, continues its mission “to strengthen national and local health systems and improve the health of the peoples of the Americas.” en.wikipedia.org/wiki/Pan_Ameri…
A PAHO summary, U.S. AT WAR. MYSTERY VIRUS LEAPS AROUND
7:36 PM · Jan 6, 2025 · 152 Views
1 Reply · 1 Like
105 Nature will take care of size reductions
3in5saved@3in5saved
Healthy immune function prevents viral replication and therefore viral mutation. As with comorbid humans unable to fight off say SARS-CoV-2 infections leading to immune dysregulation, organ damage, and then death, what of the billions of animals in our keep?
At last report, “of
6:50 PM · Feb 5, 2025 · 167 Views
106 We should use all tools made available
3in5saved@3in5saved
Here are the total deaths in the US attributed to covid since #Gohibic became commercially available on June 21, 2023. covid.cdc.gov/covid-data-tra…
2023: 33,846 deaths (during the remainder of the year)
2024: 47,169 deaths
2025: 5269 deaths (so far, noting a reporting lag of 2-4
IDSA @IDSAInfo
In adults hospitalized with critical COVID-19, should #vilobelimab compared to no vilobelimab be added to standard care?
A focused update on vilobelimab is now available via #IDSAGuidelines: https://t.co/sGTOU2F5lf
3:24 PM · Feb 24, 2025 · 351 Views
1 Reply · 3 Reposts · 4 Likes
107 A bad case of PG
3in5saved@3in5saved
Ryan Becker of Spokane, Washington, I sincerely wish you the best, and for your wife and your six kids. Immune dysregulation – uncontrolled inflammation – is an ever-increasing healthcare challenge to say the least. dailymail.co.uk/news/article-1…
There is hope on the horizon:
3:56 PM · Mar 13, 2025 · 363 Views
2 Replies · 3 Likes
108 Vilo in PG?
3in5saved@3in5saved
#Gohibic (Vilo) #InflaRx $IFRX
Eculizumab blocks C5, therefore partially reducing C5a-C5aR signaling but also preventing important functions (of the MAC) such as killing infectious bacterial cells. Vilo fully controls C5a levels without impacting MAC functions.
Eculizumab was
@StreetCred2018 @StreetCred2017
P3 PG due in 0-10 days
P2 CSU due in 30-90 days
P2 HS due in 30-90 days
P3 BARDA for #ARDS due 6-24 months
GOHIBIC approved in Europe w ARDS label - EMA US for severe COVID.
$IFRX may be most undervalued biotech $XBI
@Quick2smile @BioStocks @Biotech2k1 @Maximus_Holla
8:14 PM · May 25, 2025 · 1.05K Views
1 Reply · 3 Reposts · 5 Likes
109 Not acceptable leadership
3in5saved@3in5saved
#IDSA #InflaRx #BARDA #Gohibic
There’s been growing coverage of late regarding the latest SARS-CoV-2 subvariants, Nimbus and now Stratus. Add the ongoing debate about the efficacy/safety of vaccines, and one must ask, in concern of their own health safety and that of their
5:44 PM · Aug 9, 2025 · 698 Views
1 Repost · 1 Like
110 Vilo/904 presentations, a point in time
3in5saved@3in5saved
#InflaRx $IFRX #Gohibic #INF904
A couple of events on the horizon showcasing InflaRx C5a-C5aR1 signaling control biotech.
Anti-C5a Vilobelimab, currently in a BARDA-funded ARDS study, still seems to be of interest in treatment of Pyoderma Gangrenosum (PG). But then why not
3:37 PM · Aug 24, 2025 · 1.19K Views
1 Reply · 2 Reposts · 3 Likes
111 Finding the right treatment takes decades
3in5saved@3in5saved
#Gohibic (vilobelimab)
Dr. Ortega is likely back in Portland now after his trip to Paris, amongst other things to present “Spotlight on Pyoderma Gangrenosum.” eadvapps.m-anage.com/eadvcongress20…
There isn’t nearly as much clinical study currently going on in PG as compared to HS, likely
4:35 PM · Sep 20, 2025 · 212 Views
1 Like
112 Paradigm-level anti-inflammatory therapy
3in5saved@3in5saved
#InflaRx #INF904 “If a twice-daily oral drug could maintain CD11b expression near baseline in a patient whose disease would otherwise drive 13 nM C5a, that would represent a major therapeutic breakthrough in neutrophil-driven inflammatory disease. It would represent a
3:44 PM · Oct 11, 2025 · 481 Views
1 Repost · 5 Likes
113 Bye-bye draining tunnels
3in5saved@3in5saved
#InflaRx #HS #INF904 Now there’s a trigger, like a bunch of CD11b integrins called to action ;)
We don’t need AI to put this puzzle together.
Vilo-HS p2a dosing was 800mg/wk. Topline: “In the study, all twelve patients were categorized as Hurley Stage III and therefore most
@StreetCred2018 @StreetCred2017
@BioValues It would be interesting if someone would put this exact study in ai and find out how INF904 would do instead of vilobelimab. Also pill vs not.
The timing of this 3 days ago likely not coincidence for Inflarx $IFRX
@3in5saved
https://t.co/M84Y2jU3K5
9:00 PM · Oct 16, 2025 · 4.66K Views
5 Replies · 1 Repost · 9 Likes
114 Hashtag common sense healthcare
3in5saved@3in5saved
Hashtag common sense healthcare.
P1: In the immunodermatology field, of all the indications that have approved drugs, how many of them require 100% resolution vs partial or even 0% resolution of a severe component of the disease? I want to get a sense of how rare a PG treatment
3:47 PM · Oct 20, 2025 · 211 Views
1 Reply · 2 Likes
115 Stay ahead of the curve
3in5saved@3in5saved
$IFRX #InflaRx “expects to host a webcast/conference call accompanied by a slide presentation on Monday, November 10, 2025, at 8:00 AM EST / 2:00 PM CET to discuss the [HS and CSU] topline clinical data, and to also feature key opinion leader insight.” inflarx.de/Home/Investors…
An
3in5saved @3in5saved
Thank you #InflaRx $IFRX for organizing the recent R&D Event which detailed the exciting promise of oral C5aR inhibitor, #INF904. Both the presentation and a recording of the webcast are now available at https://t.co/4FlZGkF2Yp.
Some Highlights
▶️page 16: the C5a-C5aR
4:29 PM · Nov 8, 2025 · 59 Views
116 Neutrophil hyperactivity and tunnels
3in5saved@3in5saved
$IFRX Here’s my favorite slide from today’s presentation (available here inflarx.de/Home/Investors…).
People can jump and down all they want about open label vs placebo controlled, but in the brilliance of HiSCR, which only cares about reduction of lesions that spontaneously heal
Martin Shkreli @MartinShkreli
i like the $IFRX data, congrats to them--better than $MLTX!
6:17 PM · Nov 10, 2025 · 5.5K Views
5 Reposts · 14 Likes
117 PG is a neutrophilic dermatosis
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$IFRX #InflaRx #vilobelimab New paper out, coauthored by Dr. Ortega who has been (was?) treating the worst PG case ever identified, of a patient who hopes that $22k per month in donations will sustain his supply of anti-IL23 Tremfya, assumed to be that which is keeping him alive
1:23 PM · Nov 12, 2025 · 762 Views
2 Replies · 2 Likes
118 Nu.Q® NETs, as a marker of NETosis
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Nu.Q® NETs, as a marker of NETosis, is an important development in enabling a reliable, economical test of neutrophil hyperactivity, as demonstrated here in study of HS severity assessment and subsequent treatment outcome, noting that “circulating H3.1-nucleosome levels reflect
Volition @VolitionRx
"I am delighted to present data from the recently released clinical study demonstrating the use of Volition’s Nu.Q® NETs assay in patient management for HS, a chronic lifelong disease, which affects approximately 1% of the world’s population," shared Professor Evangelos J.
7:26 PM · Feb 4, 2026 · 361 Views
2 Likes
119 Three diseases most doctors can’t spell
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$IFRX #InflaRx #HS #PG #AAV
🔷Hidradenitis suppurativa🔷Pyoderma gangrenosum🔷ANCA vasculitis
Three diseases most doctors can't spell.
Millions of patients. Years to diagnosis. Treatments that half-work at best.
Same broken biology underneath all three.
Same upstream fix
2:51 PM · Mar 11, 2026 · 19 Views
120 IgA nephropathy, a story
3in5saved@3in5saved
#InflaRx #izicopan #IgAN – IgA nephropathy – is a kidney disease caused by antibodies going wrong and inflaming the kidney’s own filtering units, eventually ending in organ failure. That frames the story.
This is the story. She is in her late twenties. She feels well. Her
4:45 PM · Mar 15, 2026 · 149 Views
4 Replies · 1 Like